Anupam Kumar, PhD
My research interest is to understand the interplay between tumor cells and the immune cells in the brain tumor microenvironment. In particular, I’m interested in understanding the potential interactions between BRAF signaling and the immune response in BRAF altered gliomas. Outside the lab, I enjoy watching movies and listening music.
2007 - 2009: Masters of Science, Biomedical Genetics, VIT University, India
2010 - 2012: Research Associate Indian Institute of Technology (IIT), Madras, India
2012 - 2013: Senior Research Fellow, All India Institute of Medical Science (AIIMS), India
2013 - 2018: PhD in Neurooncology, All India Institute of Medical Science (AIIMS), India
2018 - Present: Postdoctoral Fellow, UCSF, San Francisco, USA
2017: Best Abstract Award, Indian Society of Neuro-oncology (ISNOCON), India
2015: International conference Travel Grant, Department of Science and Technology (DST), India
2014: Best Poster Award, Delhi Neurological Association (DNACON), India
2014 - 2017: Senior Research Fellowship (SRF), Indian Council of Medical Research (ICMR), India
2007: Gold Medalist in Chemistry and Zoology during Bachelor’s degree
2002: Certificate of distinctive performance in National Science Olympiad, India
Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM
McKinney A, Lindberg OR, Engler JR, Chen KY, Kumar A, Gong H, Lu KV, Simonds EF, Cloughesy TF, Liau LM, Prados M, Bollen AW, Berger MS, Shieh JTC, James CD,Nicolaides TP, Yong WH, Lai A, Hegi ME, Weiss WA, Phillips JJ.
Mol Cancer Ther. 2019 Sep;18(9):1565-1576. Epub 2019 Jul 3.
Identification of miR-379/miR-656 (C14MC) cluster downregulation and associated epigenetic and transcription regulatory mechanism in oligodendrogliomas
Kumar A, Nayak S, Pathak P, Purkait S, Malgulawar PB, Sharma MC, Suri V, Mukhopadhyay A, Suri A, Sarkar C.
J Neurooncol. 2018 Jun 21. doi: 10.1007/s11060-018-2840-6. [Epub ahead of print]
Novel internal regulators and candidate miRNAs within miR-379/miR-656 miRNA cluster can alter cellular phenotype of human glioblastoma
Nayak S, Aich M, Kumar A, Sengupta S, Bajad P, Dhapola P, Paul D, Narta K, Purkrait S, Mehani B, Suri A, Chakraborty D, Mukhopadhyay A, Sarkar C.
Sci Rep. 2018 May 16;8(1):7673. doi: 10.1038/s41598-018-26000-8.
Oncogenic KIAA1549-BRAF fusion with activation of the MAPK/ERK pathway in pediatric oligodendrogliomas
Kumar A, Pathak P, Purkait S, Faruq M, Jha P, Mallick S, Suri V, Sharma MC, Suri A, Sarkar C.
Cancer Genet. 2015 Mar;208(3):91-5. doi: 10.1016/j.cancergen.2015.01.009. Epub 2015 Feb 20.
Genetic alterations related to BRAF-FGFR genes and dysregulated MAPK/ERK/mTOR signaling in adult pilocytic astrocytoma
Pathak P, Kumar A, Jha P, Purkait S, Faruq M, Suri A, Suri V, Sharma MC, Sarkar C.
Brain Pathol. 2017 Sep;27(5):580-589. doi: 10.1111/bpa.12444. Epub 2017 Jan 6.
Clinicopathological and molecular characteristics of pediatric meningiomas
Battu S*, Kumar A*, Pathak P, Purkait S, Dhawan L, Sharma MC, Suri A, Singh M, Sarkar C, Suri V.
Neuropathology. 2018 Feb;38(1):22-33. doi: 10.1111/neup.12426. Epub 2017 Sep 13. PubMed PMID: 28901666.
Meningeal hemangiopericytomas: a clinicopathological study with emphasis on MGMT (O(6) -methylguanine-DNA methyltransferase) promoter methylation status
Kakkar A*, Kumar A*, Jha P, Goyal N, Mallick S, Sharma MC, Suri A, Singh M, Kale SS, Julka PK, Sarkar C, Suri V.
Neuropathology. 2014 Aug;34(4):333-42. doi: 10.1111/neup.12107. Epub 2014 Feb 12. PubMed PMID: 24521400.
Loss-of-Function Mutations in Calcitonin Receptor (CALCR) Identify Highly Aggressive Glioblastoma with Poor Outcome
Pal J, Patil V, Kumar A, Kaur K, Sarkar C, Somasundaram K.
Clin Cancer Res. 2018 Mar 15;24(6):1448-1458. doi: 10.1158/1078-0432.CCR-17-1901. Epub 2017 Dec 20.
Clinicopathological characteristics, molecular subgrouping, and expression of miR-379/miR-656 cluster (C14MC) in adult medulloblastomas
Kaur K, Kakkar A, Kumar A, Purkait S, Mallick S, Suri V, Sharma MC, Julka PK, Gupta D, Suri A, Sarkar C.
J Neurooncol. 2016 Dec;130(3):423-430. Epub 2016 Aug 30. PubMed PMID: 27576698.
BRAF gene alterations and enhanced mammalian target of rapamycin signaling in gangliogliomas
Kakkar A, Majumdar A, Pathak P, Kumar A, Kumari K, Tripathi M, Sharma MC, Suri V, Tandon V, Chandra SP, Sarkar C.
Neurol India. 2017 Sep-Oct;65(5):1076-1082. doi: 10.4103/neuroindia.NI_207_17.
Telomerase reverse transcriptase (TERT) - enhancer of zeste homolog 2 (EZH2) network regulates lipid metabolism and DNA damage responses in glioblastoma
Ahmad F, Patrick S, Sheikh T, Sharma V, Pathak P, Malgulwar PB, Kumar A, Joshi SD, Sarkar C, Sen E.
J Neurochem. 2017 Dec;143(6):671-683. doi: 10.1111/jnc.14152. Epub 2017 Sep 22.
Alterations in BRAF gene, and enhanced mTOR and MAPK signaling in dysembryoplastic neuroepithelial tumors (DNTs)
Kakkar A, Majumdar A, Kumar A, Tripathi M, Pathak P, Sharma MC, Suri V, Tandon V, Chandra SP, Sarkar C.
Epilepsy Res. 2016 Nov;127:141-151. doi: 10.1016/j.eplepsyres.2016.08.028. Epub 2016 Aug 28.
ATRX loss in glioneuronal tumors with neuropil-like islands indicates similarity to diffuse astrocytic tumors
Kakkar A, Nambirajan A, Kaur K, Kumar A, Mallick S, Suri V, Sarkar C, Kale SS, Garg A, Sharma MC.
J Neurooncol. 2016 Oct;130(1):63-68. Epub 2016 Jul 28.
Prognostic Stratification of GBMs Using Combinatorial Assessment of IDH1 Mutation, MGMT Promoter Methylation, and TERT Mutation Status: Experience from a Tertiary Care Center in India
Purkait S, Mallick S, Sharma V, Kumar A, Pathak P, Jha P, Biswas A, Julka PK, Gupta D, Suri A, Datt Upadhyay A, Suri V, Sharma MC, Sarkar C.
Transl Oncol. 2016 Aug;9(4):371-6. doi: 10.1016/j.tranon.2016.06.005. PubMed PMID: 27567961; PubMed Central PMCID: PMC5006811.
Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma
Ahmad F, Dixit D, Sharma V, Kumar A, Joshi SD, Sarkar C, Sen E.
Cell Death Dis. 2016 May 5;7:e2213. doi: 10.1038/cddis.2016.117.
Expression of DNA methyltransferases 1 and 3B correlates with EZH2 and this 3-marker epigenetic signature predicts outcome in glioblastomas
Purkait S, Sharma V, Kumar A, Pathak P, Mallick S, Jha P, Sharma MC, Suri V, Julka PK, Suri A, Sharma BS, Sarkar C.
Exp Mol Pathol. 2016 Apr;100(2):312-20. doi: 10.1016/j.yexmp.2016.02.002. Epub 2016 Feb 15. PubMed PMID: 26892683.
A simplified approach for molecular classification of glioblastomas (GBMs): experience from a tertiary care center in India
Purkait S, Mallick S, Sharma V, Kumar A, Pathak P, Jha P, Biswas A, Julka PK, Gupta D, Suri A, Upadhyay AD, Suri V, Sharma MC, Sarkar C.
Brain Tumor Pathol. 2016 Jul;33(3):183-90. doi: 10.1007/s10014-016-0251-y. Epub 2016 Feb 10. PubMed PMID: 26865311.
ATRX in Diffuse Gliomas With its Mosaic/Heterogeneous Expression in a Subset
Purkait S, Miller CA, Kumar A, Sharma V, Pathak P, Jha P, Sharma MC, Suri V, Suri A, Sharma BS, Fulton RS, Kale SS, Dahiya S, Sarkar C.
Brain Pathol. 2017 Mar;27(2):138-145. doi: 10.1111/bpa.12364. Epub 2016 Jun 13. PubMed PMID: 26833422.
Analysis of EZH2: micro-RNA network in low and high grade astrocytic tumors
Sharma V, Purkait S, Takkar S, Malgulwar PB, Kumar A, Pathak P, Suri V, Sharma MC, Suri A, Kale SS, Kulshreshtha R, Sarkar C.
Brain Tumor Pathol. 2016 Apr;33(2):117-28. doi: 10.1007/s10014-015-0245-1. Epub 2016 Jan 8. PubMed PMID: 26746204.
1p/14q co-deletion: A determinant of recurrence in histologically benign meningiomas
Kakkar A, Kumar A, Das A, Pathak P, Sharma MC, Singh M, Suri A, Sarkar C, Suri V.
Indian J Pathol Microbiol. 2015 Oct-Dec;58(4):433-8. doi: 10.4103/0377-4929.168852. PubMed PMID: 26549062.
Integrating Molecular Subclassification of Medulloblastomas into Routine Clinical Practice: A Simplified Approach
Kaur K, Kakkar A, Kumar A, Mallick S, Julka PK, Gupta D, Suri A, Suri V, Sharma MC, Sarkar C.
Brain Pathol. 2016 May;26(3):334-43. doi: 10.1111/bpa.12293. Epub 2015 Sep 9.
Outcomes of pediatric glioblastoma treated with adjuvant chemoradiation with temozolomide and correlation with prognostic factors
Mallick S, Gandhi AK, Joshi NP, Kumar A, Puri T, Sharma DN, Haresh KP, Gupta S, Julka PK, Rath GK, Sarkar C.
Indian J Med Paediatr Oncol. 2015 Apr-Jun;36(2):99-104. doi: 10.4103/0971-5851.158838. PubMed PMID: 26157286; PubMed Central PMCID: PMC4477385.
Genome-wide small noncoding RNA profiling of pediatric high-grade gliomas reveals deregulation of several miRNAs, identifies downregulation of snoRNA cluster HBII-52 and delineates H3F3A and TP53 mutant-specific miRNAs and snoRNAs
Jha P, Agrawal R, Pathak P, Kumar A, Purkait S, Mallik S, Suri V, Chand Sharma M, Gupta D, Suri A, Sharma BS, Julka PK, Kulshreshtha R, Sarkar C.
Int J Cancer. 2015 Nov 15;137(10):2343-53. doi: 10.1002/ijc.29610. Epub 2015 Jun 3.
Evaluation of 1p and 14q status, MIB-1 labeling index and progesterone receptor immunoexpression in meningiomas: Adjuncts to histopathological grading and predictors of aggressive behavior
Kumar S, Kakkar A, Suri V, Kumar A, Bhagat U, Sharma MC, Singh M, Suri A, Sarkar C.
Neurol India. 2014 Jul-Aug;62(4):376-82. doi: 10.4103/0028-3886.141248.