Tumor Evolution and the Development of Improved Disease Biomarkers

Tumor Evolution and the Development of Improved Disease Biomarkers

The spatial and longitudinal analysis of human tumor tissue is critical to better understand tumor evolution and mechanisms of progression and therapeutic resistance. Working as part of a multi-disciplinary team of investigators we are investigating the cellular landscape of diffuse glioma with the goal of defining determinants of disease progression. We will first define the degree of intratumoral and intertumoral heterogeneity at the cellular- and protein-level across diffuse gliomas.  We will then determine whether this pattern is altered at disease progression.

 

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