Phillips Lab at UCSF

Publications

The following includes a selection of recent publications from our lab. View the complete list here on PubMed.

 

An oncolytic measles virus-sensitive Group 3 medulloblastoma model in immune-competent mice

Lal S, Carrera D, Phillips JJ, Weiss WA, Raffel C.

Neuro Oncol. 2018 Nov 12; 20 (12): 1606-1615. doi: 10.1093/neuonc/noy089.
PubMed Link >

Pro-angiogenic cellular and genomic expression patterns within glioblastoma influences dynamic susceptibility weighted perfusion MRI

Barajas RF Jr, Phillips JJ, Vandenberg SR, McDermott MW, Berger MS, Dillon WP, Cha S.

Clin Radiol. 2015; 70 (10): 1087-95. doi: 10.1016/j.crad.2015.03.006. Epub 2015 Jul 29.
PubMed Link >

Protein Analysis of Glioblastoma Primary and Posttreatment Pairs Suggests a Mesenchymal Shift at Recurrence

Wood MD, Reis GF, Reuss DE, Phillips JJ.

J Neuropathol Exp Neurol. 2016; 75 (10): 925-935. Epub 2016 Aug 18.
PubMed Link >

Relationship of In Vivo MR Parameters to Histopathological and Molecular Characteristics of Newly Diagnosed, Nonenhancing Lower-Grade Gliomas

Luks TL, McKnight TR, Jalbert LE, Williams A, Neill E, Lobo KA, Persson AI, Perry A, Phillips JJ, Molinaro AM, Chang SM, Nelson SJ.

Transl Oncol. 2018; 11 (4): 941-949. doi: 10.1016/j.tranon.2018.05.005. Epub 2018 Jun 18.
PubMed Link >

Characterization of Metabolic, Diffusion, and Perfusion Properties in GBM: Contrast-Enhancing versus Non-Enhancing Tumor

Autry A, Phillips JJ, Maleschlijski S, Roy R, Molinaro AM, Chang SM, Cha S, Lupo JM, Nelson SJ.

Transl Oncol. 2017; 10 (6): 895-903. doi: 10.1016/j.tranon.2017.08.009. Epub 2017 Sep 22.
PubMed Link >

MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival

Radoul M, Chaumeil MM, Eriksson P, Wang AS, Phillips JJ, Ronen SM.

Mol Cancer Ther. 2016; 15 (5): 1113-22. doi: 10.1158/1535-7163.MCT-15-0769. Epub 2016 Feb 16.
PubMed Link >

Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner

Viswanath P, Radoul M, Izquierdo-Garcia JL, Luchman HA, Gregory Cairncross J, Pieper RO, Phillips JJ, Ronen SM.

Cancer Metab. 2018 Apr 3; 6: 3. doi: 10.1186/s40170-018-0178-3. eCollection 2018.
PubMed Link >

Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1

Mazor T, Chesnelong C, Pankov A, Jalbert LE, Hong C, Hayes J, Smirnov IV, Marshall R, Souza CF, Shen Y, Viswanath P, Noushmehr H, Ronen SM, Jones SJM, Marra MA, Cairncross JG, Perry A, Nelson SJ, Chang SM, Bollen AW, Molinaro AM, Bengtsson H, Olshen AB, Weiss S, Phillips JJ, Luchman HA, Costello JF.

Proc Natl Acad Sci U S A. 2017 Oct 3; 114 (40): 10743-10748. doi: 10.1073/pnas.1708914114. Epub 2017 Sep 15.
PubMed Link >

Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells

Lerner RG, Grossauer S, Kadkhodaei B, Meyers I, Sidorov M, Koeck K, Hashizume R, Ozawa T, Phillips JJ, Berger MS, Nicolaides T, James CD, Petritsch CK.

Cancer Res. 2015 Dec 15; 75 (24): 5355-66. doi: 10.1158/0008-5472.CAN-14-3689. Epub 2015 Nov 16.
PubMed Link >

Loss of H3K27 trimethylation by immunohistochemistry is frequent in oligodendroglioma, IDH-mutant and 1p/19q-codeleted, but is neither a sensitive nor a specific marker

Pekmezci M, Phillips JJ, Dirilenoglu F, Atasever-Rezanko T, Tihan T, Solomon D, Bollen A, Perry A.

Acta Neuropathol. 2020 Jan 7; doi: 10.1007/s00401-019-02123-8. [Epub ahead of print].
PubMed Link >

Comprehensive Molecular Profiling Identifies FOXM1 as a Key Transcription Factor for Meningioma Proliferation

Vasudevan HN, Braunstein SE, Phillips JJ, Pekmezci M, Tomlin BA, Wu A, Reis GF, Magill ST, Zhang J, Feng FY, Nicholaides T, Chang SM, Sneed PK, McDermott MW, Berger MS, Perry A, Raleigh DR.

Cell Rep. 2018 Mar 27; 22 (13): 3672-3683. doi: 10.1016/j.celrep.2018.03.013.
PubMed Link >

Heparan Sulfate Glycosaminoglycans in Glioblastoma Promote Tumor Invasion

Tran VM, Wade A, McKinney A, Chen K, Lindberg OR, Engler JR, Persson AI, Phillips JJ.

Mol Cancer Res. 2017; 15 (11): 1623-1633. doi: 10.1158/1541-7786.MCR-17-0352. Epub 2017 Aug 4.
PubMed Link >

Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas

Sloan EA, Cooney T, Oberheim Bush NA, Buerki R, Taylor J, Clarke JL, Torkildson J, Kline C, Reddy A, Mueller S, Banerjee A, Butowski N, Chang S, Mummaneni PV, Chou D, Tan L, Theodosopoulos P, McDermott M, Berger M, Raffel C, Gupta N, Sun PP, Li Y, Shah V, Cha S, Braunstein S, Raleigh DR, Samuel D, Scharnhorst D, Fata C, Guo H, Moes G, Kim JYH, Koschmann C, Van Ziffle J, Onodera C, Devine P, Grenert JP, Lee JC, Pekmezci M, Phillips JJ, Tihan T, Bollen AW, Perry A, Solomon DA.

Acta Neuropathol. 2019; 138 (5): 877-881. doi: 10.1007/s00401-019-02072-2. Epub 2019 Sep 12.
PubMed Link >

The Phenotypes of Proliferating Glioblastoma Cells Reside on a Single Axis of Variation.

Wang L, Babikir H, Müller S, Yagnik G, Shamardani K, Catalan F, Kohanbash G, Alvarado B, Di Lullo E, Kriegstein A, Shah S, Wadhwa H, Chang SM, Phillips JJ, Aghi MK, Diaz AA.

Cancer Discov. 2019; 9 (12): 1708-1719. doi: 10.1158/2159-8290.CD-19-0329. Epub 2019 Sep 25.
PubMed Link >

A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle

Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips JJ, Wiita AP, Yeh I, Jacobson MP, Bastian BC, Perry A, Solomon DA.

Nat Commun. 2018 Feb 23; 9 (1): 810. doi: 10.1038/s41467-018-02826-8.
PubMed Link >