Phillips Lab at UCSF

Publications

The following includes a selection of recent publications from our lab. View the complete list here on PubMed.

 

Quantitative Assessment of Preanalytic Variables on Clinical Evaluation of PI3/AKT/mTOR Signaling Activity in Diffuse Glioma

Beccari S, Mohamed E, Voong V, Hilz S, Lafontaine M, Shai A, Lim Y, Martinez J, Switzman B, Yu RL, Lupo JM, Chang EF, Hervey-Jumper SL, Berger MS, Costello JF, Phillips JJ.

Mod Pathol. 2024 Jun 1; 37 (6): 100488. doi: 10.1016/j.modpat.2024.100488. Epub 2024 Apr 6.
PubMed Link >

PI3K/AKT/mTOR signaling pathway activity in IDH-mutant diffuse glioma and clinical implications

Mohamed E, Kumar A, Zhang Y, Wang AS, Chen K, Lim Y, Shai A, Taylor JW, Clarke J, Hilz S, Berger MS, Solomon DA, Costello JF, Molinaro AM, Phillips JJ.

Neuro Oncol. 2022 Sep 1; 24 (9): 1471-1481. doi: 10.1093/neuonc/noac064.
PubMed Link >

CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma

Kumar A, Mohamed E, Tong S, Chen K, Mukherjee J, Lim Y, Wong CM, Boosalis Z, Shai A, Pieper RO, Gupta N, Perry A, Bollen AW, Molinaro AM, Solomon DA, Shieh JTC, Phillips JJ.

Clin Cancer Res. 2022 Jul 1; 28 (13): 2898-2910. doi: 10.1158/1078-0432.CCR-21-2830.
PubMed Link >

Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective

Mathur R, Wang Q, Schupp PG, Nikolic A, Hilz S, Hong C, Grishanina NR, Kwok D, Stevers NO, Jin Q, Youngblood MW, Stasiak LA, Hou Y, Wang J, Yamaguchi TN, Lafontaine M, Shai A, Smirnov IV, Solomon DA, Chang SM, Hervey-Jumper SL, Berger MS, Lupo JM, Okada H, Phillips JJ, Boutros PC, Gallo M, Oldham MC, Yue F, Costello JF.

Cell. 2024 Jan 18; 187 (2): 446-463.e16. doi: 10.1016/j.cell.2023.12.013.
PubMed Link >

Cellular architecture of human brain metastases

Gonzalez H, Mei W, Robles I, Hagerling C, Allen BM, Hauge Okholm TL, Nanjaraj A, Verbeek T, Kalavacherla S, van Gogh M, Georgiou S, Daras M, Phillips JJ, Spitzer MH, Roose JP, Werb Z.

Cell. 2022 Feb 17; 185 (4): 729-745.e20. doi: 10.1016/j.cell.2021.12.043. Epub 2022 Jan 20..
PubMed Link >

A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets

Wang L, Jung J, Babikir H, Shamardani K, Jain S, Feng X, Gupta N, Rosi S, Chang S, Raleigh D, Solomon D, Phillips JJ, Diaz AA.

Nat Cancer. 2022 Dec 1; 3 (12): 1534-1552. doi: 10.1038/s43018-022-00475-x. Epub 2022 Dec 20..
PubMed Link >

Loss of H3K27 trimethylation by immunohistochemistry is frequent in oligodendroglioma, IDH-mutant and 1p/19q-codeleted, but is neither a sensitive nor a specific marker

Pekmezci M, Phillips JJ, Dirilenoglu F, Atasever-Rezanko T, Tihan T, Solomon D, Bollen A, Perry A.

Acta Neuropathol. 2020 Jan 7; doi: 10.1007/s00401-019-02123-8. [Epub ahead of print].
PubMed Link >

The Phenotypes of Proliferating Glioblastoma Cells Reside on a Single Axis of Variation.

Wang L, Babikir H, Müller S, Yagnik G, Shamardani K, Catalan F, Kohanbash G, Alvarado B, Di Lullo E, Kriegstein A, Shah S, Wadhwa H, Chang SM, Phillips JJ, Aghi MK, Diaz AA.

Cancer Discov. 2019; 9 (12): 1708-1719. doi: 10.1158/2159-8290.CD-19-0329. Epub 2019 Sep 25.
PubMed Link >

Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas

Sloan EA, Cooney T, Oberheim Bush NA, Buerki R, Taylor J, Clarke JL, Torkildson J, Kline C, Reddy A, Mueller S, Banerjee A, Butowski N, Chang S, Mummaneni PV, Chou D, Tan L, Theodosopoulos P, McDermott M, Berger M, Raffel C, Gupta N, Sun PP, Li Y, Shah V, Cha S, Braunstein S, Raleigh DR, Samuel D, Scharnhorst D, Fata C, Guo H, Moes G, Kim JYH, Koschmann C, Van Ziffle J, Onodera C, Devine P, Grenert JP, Lee JC, Pekmezci M, Phillips JJ, Tihan T, Bollen AW, Perry A, Solomon DA.

Acta Neuropathol. 2019; 138 (5): 877-881. doi: 10.1007/s00401-019-02072-2. Epub 2019 Sep 12.
PubMed Link >

Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM

McKinney A, Lindberg OR, Engler JR, Chen KY, Kumar A, Gong H, Lu KV, Simonds EF, Cloughesy TF, Liau LM, Prados M, Bollen AW, Berger MS, Shieh JTC, James CD, Nicolaides TP, Yong WH, Lai A, Hegi ME, Weiss WA, Phillips JJ.

Mol Cancer Ther. 2019; 18 (9): 1565-1576. doi: 10.1158/1535-7163.MCT-18-1330. Epub 2019 Jul 3.
PubMed Link >

Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma

Lee JC, Mazor T, Lao R, Wan E, Diallo AB, Hill NS, Thangaraj N, Wendelsdorf K, Samuel D, Kline CN, Banerjee A, Auguste K, Raffel C, Gupta N, Berger M, Raleigh DR, Shai A, Phillips JJ, Bollen AW, Tihan T, Perry A, Costello J, Solomon DA.

Acta Neuropathol. 2019 Jan 16; 137 (5): 851-854. doi: 10.1007/s00401-019-01990-5. Epub 2019 Mar 14.
PubMed Link >

High density is a property of slow-cycling and treatment-resistant human glioblastoma cells

Sabelström H, Quigley DA, Fenster T, Foster DJ, Fuchshuber CAM, Saxena S, Yuan E, Li N, Paterno F, Phillips JJ, James CD, Norling B, Berger MS, Persson AI.

Exp Cell Res. 2019 May 1; 378 (1): 76-86. doi: 10.1016/j.yexcr.2019.03.003. Epub 2019 Mar 5.
PubMed Link >

The genetic landscape of gliomas arising after therapeutic radiation

López GY, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Clarke J, Oberheim Bush NA, Taylor J, Chang S, Butowski N, Banerjee A, Mueller S, Kline C, Torkildson J, Samuel D, Siongco A, Raffel C, Gupta N, Kunwar S, Mummaneni P, Aghi M, Theodosopoulos P, Berger M, Phillips JJ, Pekmezci M, Tihan T, Bollen AW, Perry A, Solomon DA.

Acta Neuropathol. 2019; 137 (1): 139-150. doi: 10.1007/s00401-018-1906-z. Epub 2018 Sep 8.
PubMed Link >

Phase-2 trial of palbociclib in adult patients with recurrent RB1-positive glioblastoma

Taylor JW, Parikh M, Phillips JJ, James CD, Molinaro AM, Butowski NA, Clarke JL, Oberheim-Bush NA, Chang SM, Berger MS, Prados M.

J Neurooncol. 2018; 140 (2): 477-483. doi: 10.1007/s11060-018-2977-3. Epub 2018 Aug 27.
PubMed Link >

An oncolytic measles virus-sensitive Group 3 medulloblastoma model in immune-competent mice

Lal S, Carrera D, Phillips JJ, Weiss WA, Raffel C.

Neuro Oncol. 2018 Nov 12; 20 (12): 1606-1615. doi: 10.1093/neuonc/noy089.
PubMed Link >