Phillips Lab at UCSF


The following includes a selection of recent publications from our lab. View the complete list here on PubMed.


Loss of H3K27 trimethylation by immunohistochemistry is frequent in oligodendroglioma, IDH-mutant and 1p/19q-codeleted, but is neither a sensitive nor a specific marker

Pekmezci M, Phillips JJ, Dirilenoglu F, Atasever-Rezanko T, Tihan T, Solomon D, Bollen A, Perry A.

Acta Neuropathol. 2020 Jan 7; doi: 10.1007/s00401-019-02123-8. [Epub ahead of print].
PubMed Link >

Timing and significance of pathological features in C9orf72 expansion-associated frontotemporal dementia

Vatsavayai SC, Yoon SJ, Gardner RC, Gendron TF, Vargas JN, Trujillo A, Pribadi M, Phillips JJ, Gaus SE, Hixson JD, Garcia PA, Rabinovici GD, Coppola G, Geschwind DH, Petrucelli L, Miller BL, Seeley WW.

Brain. 2016; 139 (Pt 12): 3202-3216. Epub 2016 Oct 22.
PubMed Link >

Comprehensive Molecular Profiling Identifies FOXM1 as a Key Transcription Factor for Meningioma Proliferation

Vasudevan HN, Braunstein SE, Phillips JJ, Pekmezci M, Tomlin BA, Wu A, Reis GF, Magill ST, Zhang J, Feng FY, Nicholaides T, Chang SM, Sneed PK, McDermott MW, Berger MS, Perry A, Raleigh DR.

Cell Rep. 2018 Mar 27; 22 (13): 3672-3683. doi: 10.1016/j.celrep.2018.03.013.
PubMed Link >

The Phenotypes of Proliferating Glioblastoma Cells Reside on a Single Axis of Variation.

Wang L, Babikir H, Müller S, Yagnik G, Shamardani K, Catalan F, Kohanbash G, Alvarado B, Di Lullo E, Kriegstein A, Shah S, Wadhwa H, Chang SM, Phillips JJ, Aghi MK, Diaz AA.

Cancer Discov. 2019; 9 (12): 1708-1719. doi: 10.1158/2159-8290.CD-19-0329. Epub 2019 Sep 25.
PubMed Link >

Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation

Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Jin LW, Bastian BC, Bollen AW, Perry A, Nicolaides T, Solomon DA, Shieh JT.

Acta Neuropathol. 2016; 132 (5): 757-760. Epub 2016 Sep 13.
PubMed Link >

A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle

Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips JJ, Wiita AP, Yeh I, Jacobson MP, Bastian BC, Perry A, Solomon DA.

Nat Commun. 2018 Feb 23; 9 (1): 810. doi: 10.1038/s41467-018-02826-8.
PubMed Link >

Matrix regulators in neural stem cell functions

Wade A, McKinney A, Phillips JJ.

Biochim Biophys Acta. 2014; 1840 (8): 2520-5. doi: 10.1016/j.bbagen.2014.01.017. Epub 2014 Jan 18. Review.
PubMed Link >

Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma

Han SJ, Reis G, Kohanbash G, Shrivastav S, Magill ST, Molinaro AM, McDermott MW, Theodosopoulos PV, Aghi MK, Berger MS, Butowski NA, Barani I, Phillips JJ, Perry A, Okada H.

J Neurooncol. 2016; 130 (3): 543-552. Epub 2016 Sep 13.
PubMed Link >

Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma

Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley DA, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw JK, Burdick JA, Magnitsky S, Berger MS, Phillips JJ, Arosio D, Sun D, Weaver VM, Weiss WA, Persson AI.

Mol Cancer Res. 2018; 16 (5): 777-790. doi: 10.1158/1541-7786.MCR-17-0413. Epub 2018 Feb 5.
PubMed Link >

Characterization of metabolites in infiltrating gliomas using ex vivo ¹H high-resolution magic angle spinning spectroscopy

Elkhaled A, Jalbert L, Constantin A, Yoshihara HA, Phillips JJ, Molinaro AM, Chang SM, Nelson SJ.

NMR Biomed. 2014; 27 (5): 578-93. doi: 10.1002/nbm.3097. Epub 2014 Mar 5.
PubMed Link >

Protein Analysis of Glioblastoma Primary and Posttreatment Pairs Suggests a Mesenchymal Shift at Recurrence

Wood MD, Reis GF, Reuss DE, Phillips JJ.

J Neuropathol Exp Neurol. 2016; 75 (10): 925-935. Epub 2016 Aug 18.
PubMed Link >

Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway

Pekmezci M, Stevers M, Phillips JJ, Van Ziffle J, Bastian BC, Tsankova NM, Kleinschmidt-DeMasters BK, Rosenblum MK, Tihan T, Perry A, Solomon DA.

Acta Neuropathol. 2018; 135 (3): 485-488. doi: 10.1007/s00401-018-1820-4. Epub 2018 Feb 10.
PubMed Link >

Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma

Chaumeil MM, Larson PE, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM.

Cancer Res. 2014 Aug 15; 74 (16): 4247-57. doi: 10.1158/0008-5472.CAN-14-0680. Epub 2014 May 29.
PubMed Link >

MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival

Radoul M, Chaumeil MM, Eriksson P, Wang AS, Phillips JJ, Ronen SM.

Mol Cancer Ther. 2016; 15 (5): 1113-22. doi: 10.1158/1535-7163.MCT-15-0769. Epub 2016 Feb 16.
PubMed Link >

2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas

Viswanath P, Radoul M, Izquierdo-Garcia JL, Ong WQ, Luchman HA, Cairncross JG, Huang B, Pieper RO, Phillips JJ, Ronen SM.

Cancer Res. 2018 May 1; 78 (9): 2290-2304. doi: 10.1158/0008-5472.CAN-17-2926. Epub 2018 Jan 22.
PubMed Link >