Phillips Lab at UCSF

Publications

The following includes a selection of recent publications from our lab. View the complete list here on PubMed.

 

Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells

Lerner RG, Grossauer S, Kadkhodaei B, Meyers I, Sidorov M, Koeck K, Hashizume R, Ozawa T, Phillips JJ, Berger MS, Nicolaides T, James CD, Petritsch CK.

Cancer Res. 2015 Dec 15; 75 (24): 5355-66. doi: 10.1158/0008-5472.CAN-14-3689. Epub 2015 Nov 16.
PubMed Link >

Loss of H3K27 trimethylation by immunohistochemistry is frequent in oligodendroglioma, IDH-mutant and 1p/19q-codeleted, but is neither a sensitive nor a specific marker

Pekmezci M, Phillips JJ, Dirilenoglu F, Atasever-Rezanko T, Tihan T, Solomon D, Bollen A, Perry A.

Acta Neuropathol. 2020 Jan 7; doi: 10.1007/s00401-019-02123-8. [Epub ahead of print].
PubMed Link >

Comprehensive Molecular Profiling Identifies FOXM1 as a Key Transcription Factor for Meningioma Proliferation

Vasudevan HN, Braunstein SE, Phillips JJ, Pekmezci M, Tomlin BA, Wu A, Reis GF, Magill ST, Zhang J, Feng FY, Nicholaides T, Chang SM, Sneed PK, McDermott MW, Berger MS, Perry A, Raleigh DR.

Cell Rep. 2018 Mar 27; 22 (13): 3672-3683. doi: 10.1016/j.celrep.2018.03.013.
PubMed Link >

Heparan Sulfate Glycosaminoglycans in Glioblastoma Promote Tumor Invasion

Tran VM, Wade A, McKinney A, Chen K, Lindberg OR, Engler JR, Persson AI, Phillips JJ.

Mol Cancer Res. 2017; 15 (11): 1623-1633. doi: 10.1158/1541-7786.MCR-17-0352. Epub 2017 Aug 4.
PubMed Link >

PI3K/AKT/mTOR signaling pathway activity in IDH-mutant diffuse glioma and clinical implications

Mohamed E, Kumar A, Zhang Y, Wang AS, Chen K, Lim Y, Shai A, Taylor JW, Clarke J, Hilz S, Berger MS, Solomon DA, Costello JF, Molinaro AM, Phillips JJ.

Neuro Oncol. 2022 Sep 1; 24 (9): 1471-1481. doi: 10.1093/neuonc/noac064.
PubMed Link >

Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas

Sloan EA, Cooney T, Oberheim Bush NA, Buerki R, Taylor J, Clarke JL, Torkildson J, Kline C, Reddy A, Mueller S, Banerjee A, Butowski N, Chang S, Mummaneni PV, Chou D, Tan L, Theodosopoulos P, McDermott M, Berger M, Raffel C, Gupta N, Sun PP, Li Y, Shah V, Cha S, Braunstein S, Raleigh DR, Samuel D, Scharnhorst D, Fata C, Guo H, Moes G, Kim JYH, Koschmann C, Van Ziffle J, Onodera C, Devine P, Grenert JP, Lee JC, Pekmezci M, Phillips JJ, Tihan T, Bollen AW, Perry A, Solomon DA.

Acta Neuropathol. 2019; 138 (5): 877-881. doi: 10.1007/s00401-019-02072-2. Epub 2019 Sep 12.
PubMed Link >

The Phenotypes of Proliferating Glioblastoma Cells Reside on a Single Axis of Variation.

Wang L, Babikir H, Müller S, Yagnik G, Shamardani K, Catalan F, Kohanbash G, Alvarado B, Di Lullo E, Kriegstein A, Shah S, Wadhwa H, Chang SM, Phillips JJ, Aghi MK, Diaz AA.

Cancer Discov. 2019; 9 (12): 1708-1719. doi: 10.1158/2159-8290.CD-19-0329. Epub 2019 Sep 25.
PubMed Link >

A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle

Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips JJ, Wiita AP, Yeh I, Jacobson MP, Bastian BC, Perry A, Solomon DA.

Nat Commun. 2018 Feb 23; 9 (1): 810. doi: 10.1038/s41467-018-02826-8.
PubMed Link >

Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy

Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA.

Neuro Oncol. 2017 May 1; 19 (5): 699-709. doi: 10.1093/neuonc/now254. Erratum in: Neuro Oncol. 2017 Apr 1;19(4):601.
PubMed Link >

Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective

Mathur R, Wang Q, Schupp PG, Nikolic A, Hilz S, Hong C, Grishanina NR, Kwok D, Stevers NO, Jin Q, Youngblood MW, Stasiak LA, Hou Y, Wang J, Yamaguchi TN, Lafontaine M, Shai A, Smirnov IV, Solomon DA, Chang SM, Hervey-Jumper SL, Berger MS, Lupo JM, Okada H, Phillips JJ, Boutros PC, Gallo M, Oldham MC, Yue F, Costello JF.

Cell. 2024 Jan 18; 187 (2): 446-463.e16. doi: 10.1016/j.cell.2023.12.013.
PubMed Link >

Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM

McKinney A, Lindberg OR, Engler JR, Chen KY, Kumar A, Gong H, Lu KV, Simonds EF, Cloughesy TF, Liau LM, Prados M, Bollen AW, Berger MS, Shieh JTC, James CD, Nicolaides TP, Yong WH, Lai A, Hegi ME, Weiss WA, Phillips JJ.

Mol Cancer Ther. 2019; 18 (9): 1565-1576. doi: 10.1158/1535-7163.MCT-18-1330. Epub 2019 Jul 3.
PubMed Link >

Matrix regulators in neural stem cell functions

Wade A, McKinney A, Phillips JJ.

Biochim Biophys Acta. 2014; 1840 (8): 2520-5. doi: 10.1016/j.bbagen.2014.01.017. Epub 2014 Jan 18. Review.
PubMed Link >

Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma

Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley DA, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw JK, Burdick JA, Magnitsky S, Berger MS, Phillips JJ, Arosio D, Sun D, Weaver VM, Weiss WA, Persson AI.

Mol Cancer Res. 2018; 16 (5): 777-790. doi: 10.1158/1541-7786.MCR-17-0413. Epub 2018 Feb 5.
PubMed Link >

Quantitative multi-modal MR imaging as a non-invasive prognostic tool for patients with recurrent low-grade glioma

Neill E, Luks T, Dayal M, Phillips JJ, Perry A, Jalbert LE, Cha S, Molinaro A, Chang SM, Nelson SJ.

J Neurooncol. 2017; 132 (1): 171-179. doi: 10.1007/s11060-016-2355-y. Epub 2017 Jan 25.
PubMed Link >

Quantitative Assessment of Preanalytic Variables on Clinical Evaluation of PI3/AKT/mTOR Signaling Activity in Diffuse Glioma

Beccari S, Mohamed E, Voong V, Hilz S, Lafontaine M, Shai A, Lim Y, Martinez J, Switzman B, Yu RL, Lupo JM, Chang EF, Hervey-Jumper SL, Berger MS, Costello JF, Phillips JJ.

Mod Pathol. 2024 Jun 1; 37 (6): 100488. doi: 10.1016/j.modpat.2024.100488. Epub 2024 Apr 6.
PubMed Link >