Esraa Mohamed, PhD
I am a postdoctoral scholar with a passion for studying signaling in Neuro-oncology. My research involves studying signaling perturbations induced in different types of glioma. I am particularly interested in assessing the degree of intratumoral and intertumoral heterogeneity in oncogenic signaling pathway activities in diffuse glioma patients and how they correlate with patient therapeutic outcomes and their overall survival. The long-term goal of my study is to develop robust disease biomarkers to improve patient stratification, which will help in implementing effective individualized treatment plans.
2019: Ph.D., Biochemistry & Molecular Biology, Virginia Commonwealth University
2007: Bachelor of Science, Pharmaceutical Sciences, Misr International University
2019 - Present: The Ruth L. Kirschstein National Research Service Award (NRSA) (T32), Training grant in translational brain tumor research, UCSF
2018: NEURO travel award, American Society for Neurochemistry (ASN)
2016-2017: Two-time recipient of the Marion Waller Scholarship Award, Virginia Commonwealth University
2015: Charles C. Clayton Fellowship, Virginia Commonwealth University
2014: Honor Society of Phi Kappa Phi Award, Virginia Commonwealth University
Myelination, Oligodendrocyte Development, and Associated Neurodevelopmental Disorders
Mohamed E, Bigbee JW, Sato-Bigbee C.
Victor Preedy (Ed.). The Neuroscience of Development, King College of London. In press.
Endogenous opioid peptides and brain development: Endomorphin-1 and Nociceptin play a sex specific role in the control of oligodendrocyte maturation and brain myelination
Mohamed E, Paisley CE, Meyer LC, Bigbee JW, Sato-Bigbee C.
GLIA. 2020. DOI: 10.1002/glia.23799
Novel role of the nociceptin system as a regulator of glutamate transporter expression in developing astrocytes
Meyer LC, Paisley CE, Mohamed E, Bigbee JW, Kordula T, Richard H, Lutfy K, Sato-Bigbee C.
GLIA. 2017, 65, 2003-2023. DOI: 10.1002/glia.23210
A causal link from ALK to hexokinase II overexpression and hyperactive glycolysis in EML4-ALK-positive lung cancer
Ma Y, Yu C, Mohamed EM, Shao H, Wang L, Sundaresan G, Zweit J, Idowu M, Fang X.
Oncogene. 2016, 35, 6132-6142. DOI: 10.1038/onc.2016.150
Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer
Shao H, Mohamed EM, Xu GG, Waters M, Jing K, Ma Y, Zhang Y, Spiegel S, Idowu MO, Fang X.
Oncotarget. 2016, 7, 3832-3846. DOI: 10.18632/oncotarget.6757
Lysophosphatidic acid up-regulates hexokinase II and glycolysis to promote proliferation of ovarian cancer cells
Mukherjee A, Ma Y, Yuan F, Gong Y, Fang Z, Mohamed EM, Berrios E, Shao H, Fang X.
Neoplasia. 2015, 17, 723-734. DOI: 10.1016/j.neo.2015.09.003
Apigenin sensitizes colon cancer cells to antitumor activity of ABT-263
Shao H, Jing K, Mahmoud E, Huang H, Fang X, Yu C.
Mol Cancer Ther. 2013, 12, 2640-2650. DOI: 10.1158/1535-7163.MCT-13-0066