Phillips Lab at UCSF

Publications

The following includes a selection of recent publications from our lab. View the complete list here on PubMed.

 

Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy

Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA.

Neuro Oncol. 2017 May 1; 19 (5): 699-709. doi: 10.1093/neuonc/now254. Erratum in: Neuro Oncol. 2017 Apr 1;19(4):601.
PubMed Link >

Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM

McKinney A, Lindberg OR, Engler JR, Chen KY, Kumar A, Gong H, Lu KV, Simonds EF, Cloughesy TF, Liau LM, Prados M, Bollen AW, Berger MS, Shieh JTC, James CD, Nicolaides TP, Yong WH, Lai A, Hegi ME, Weiss WA, Phillips JJ.

Mol Cancer Ther. 2019; 18 (9): 1565-1576. doi: 10.1158/1535-7163.MCT-18-1330. Epub 2019 Jul 3.
PubMed Link >

Matrix regulators in neural stem cell functions

Wade A, McKinney A, Phillips JJ.

Biochim Biophys Acta. 2014; 1840 (8): 2520-5. doi: 10.1016/j.bbagen.2014.01.017. Epub 2014 Jan 18. Review.
PubMed Link >

Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma

Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley DA, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw JK, Burdick JA, Magnitsky S, Berger MS, Phillips JJ, Arosio D, Sun D, Weaver VM, Weiss WA, Persson AI.

Mol Cancer Res. 2018; 16 (5): 777-790. doi: 10.1158/1541-7786.MCR-17-0413. Epub 2018 Feb 5.
PubMed Link >

Quantitative multi-modal MR imaging as a non-invasive prognostic tool for patients with recurrent low-grade glioma

Neill E, Luks T, Dayal M, Phillips JJ, Perry A, Jalbert LE, Cha S, Molinaro A, Chang SM, Nelson SJ.

J Neurooncol. 2017; 132 (1): 171-179. doi: 10.1007/s11060-016-2355-y. Epub 2017 Jan 25.
PubMed Link >

Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma

Lee JC, Mazor T, Lao R, Wan E, Diallo AB, Hill NS, Thangaraj N, Wendelsdorf K, Samuel D, Kline CN, Banerjee A, Auguste K, Raffel C, Gupta N, Berger M, Raleigh DR, Shai A, Phillips JJ, Bollen AW, Tihan T, Perry A, Costello J, Solomon DA.

Acta Neuropathol. 2019 Jan 16; 137 (5): 851-854. doi: 10.1007/s00401-019-01990-5. Epub 2019 Mar 14.
PubMed Link >

Characterization of metabolites in infiltrating gliomas using ex vivo ¹H high-resolution magic angle spinning spectroscopy

Elkhaled A, Jalbert L, Constantin A, Yoshihara HA, Phillips JJ, Molinaro AM, Chang SM, Nelson SJ.

NMR Biomed. 2014; 27 (5): 578-93. doi: 10.1002/nbm.3097. Epub 2014 Mar 5.
PubMed Link >

Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway

Pekmezci M, Stevers M, Phillips JJ, Van Ziffle J, Bastian BC, Tsankova NM, Kleinschmidt-DeMasters BK, Rosenblum MK, Tihan T, Perry A, Solomon DA.

Acta Neuropathol. 2018; 135 (3): 485-488. doi: 10.1007/s00401-018-1820-4. Epub 2018 Feb 10.
PubMed Link >

Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression

Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM.

Nat Cell Biol. 2016; 18 (12): 1336-1345. doi: 10.1038/ncb3429. Epub 2016 Nov 7.
PubMed Link >

High density is a property of slow-cycling and treatment-resistant human glioblastoma cells

Sabelström H, Quigley DA, Fenster T, Foster DJ, Fuchshuber CAM, Saxena S, Yuan E, Li N, Paterno F, Phillips JJ, James CD, Norling B, Berger MS, Persson AI.

Exp Cell Res. 2019 May 1; 378 (1): 76-86. doi: 10.1016/j.yexcr.2019.03.003. Epub 2019 Mar 5.
PubMed Link >

Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma

Chaumeil MM, Larson PE, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM.

Cancer Res. 2014 Aug 15; 74 (16): 4247-57. doi: 10.1158/0008-5472.CAN-14-0680. Epub 2014 May 29.
PubMed Link >

2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas

Viswanath P, Radoul M, Izquierdo-Garcia JL, Ong WQ, Luchman HA, Cairncross JG, Huang B, Pieper RO, Phillips JJ, Ronen SM.

Cancer Res. 2018 May 1; 78 (9): 2290-2304. doi: 10.1158/0008-5472.CAN-17-2926. Epub 2018 Jan 22.
PubMed Link >

Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process

Ohba S, Mukherjee J, Johannessen TC, Mancini A, Chow TT, Wood M, Jones L, Mazor T, Marshall RE, Viswanath P, Walsh KM, Perry A, Bell RJ, Phillips JJ, Costello JF, Ronen SM, Pieper RO.

Cancer Res. 2016 Nov 15; 76 (22): 6680-6689. doi: 10.1158/0008-5472.CAN-16-0696. Epub 2016 Oct 6.
PubMed Link >

A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma

Barnes JM, Kaushik S, Bainer RO, Sa JK, Woods EC, Kai F, Przybyla L, Lee M, Lee HW, Tung JC, Maller O, Barrett AS, Lu KV, Lakins JN, Hansen KC, Obernier K, Alvarez-Buylla A, Bergers G, Phillips JJ, Nam DH, Bertozzi CR, Weaver VM.

Nat Cell Biol. 2018; 20 (10): 1203-1214. doi: 10.1038/s41556-018-0183-3. Epub 2018 Sep 10.
PubMed Link >

SULF2, a heparan sulfate endosulfatase, is present in the blood of healthy individuals and increases in cirrhosis

Singer MS, Phillips JJ, Lemjabbar-Alaoui H, Wang YQ, Wu J, Goldman R, Rosen SD.

Clin Chim Acta. 2015 Feb 2; 440: 72-8. doi: 10.1016/j.cca.2014.10.038. Epub 2014 Oct 31.
PubMed Link >