Phillips Lab at UCSF

Publications

The following includes a selection of recent publications from our lab. View the complete list here on PubMed.

 

A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma

Barnes JM, Kaushik S, Bainer RO, Sa JK, Woods EC, Kai F, Przybyla L, Lee M, Lee HW, Tung JC, Maller O, Barrett AS, Lu KV, Lakins JN, Hansen KC, Obernier K, Alvarez-Buylla A, Bergers G, Phillips JJ, Nam DH, Bertozzi CR, Weaver VM.

Nat Cell Biol. 2018; 20 (10): 1203-1214. doi: 10.1038/s41556-018-0183-3. Epub 2018 Sep 10.
PubMed Link >

Relationship of In Vivo MR Parameters to Histopathological and Molecular Characteristics of Newly Diagnosed, Nonenhancing Lower-Grade Gliomas

Luks TL, McKnight TR, Jalbert LE, Williams A, Neill E, Lobo KA, Persson AI, Perry A, Phillips JJ, Molinaro AM, Chang SM, Nelson SJ.

Transl Oncol. 2018; 11 (4): 941-949. doi: 10.1016/j.tranon.2018.05.005. Epub 2018 Jun 18.
PubMed Link >

Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma

Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley DA, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw JK, Burdick JA, Magnitsky S, Berger MS, Phillips JJ, Arosio D, Sun D, Weaver VM, Weiss WA, Persson AI.

Mol Cancer Res. 2018; 16 (5): 777-790. doi: 10.1158/1541-7786.MCR-17-0413. Epub 2018 Feb 5.
PubMed Link >

2-Hydroxyglutarate-Mediated Autophagy of the Endoplasmic Reticulum Leads to an Unusual Downregulation of Phospholipid Biosynthesis in Mutant IDH1 Gliomas

Viswanath P, Radoul M, Izquierdo-Garcia JL, Ong WQ, Luchman HA, Cairncross JG, Huang B, Pieper RO, Phillips JJ, Ronen SM.

Cancer Res. 2018 May 1; 78 (9): 2290-2304. doi: 10.1158/0008-5472.CAN-17-2926. Epub 2018 Jan 22.
PubMed Link >

Mutant IDH1 gliomas downregulate phosphocholine and phosphoethanolamine synthesis in a 2-hydroxyglutarate-dependent manner

Viswanath P, Radoul M, Izquierdo-Garcia JL, Luchman HA, Gregory Cairncross J, Pieper RO, Phillips JJ, Ronen SM.

Cancer Metab. 2018 Apr 3; 6: 3. doi: 10.1186/s40170-018-0178-3. eCollection 2018.
PubMed Link >

Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas

Hayes J, Yu Y, Jalbert LE, Mazor T, Jones LE, Wood MD, Walsh KM, Bengtsson H, Hong C, Oberndorfer S, Roetzer T, Smirnov IV, Clarke JL, Aghi MK, Chang SM, Nelson SJ, Woehrer A, Phillips JJ, Solomon DA, Costello JF.

Neuro Oncol. 2018 Apr 9; 20 (5): 632-641. doi: 10.1093/neuonc/nox205.
PubMed Link >

Comprehensive Molecular Profiling Identifies FOXM1 as a Key Transcription Factor for Meningioma Proliferation

Vasudevan HN, Braunstein SE, Phillips JJ, Pekmezci M, Tomlin BA, Wu A, Reis GF, Magill ST, Zhang J, Feng FY, Nicholaides T, Chang SM, Sneed PK, McDermott MW, Berger MS, Perry A, Raleigh DR.

Cell Rep. 2018 Mar 27; 22 (13): 3672-3683. doi: 10.1016/j.celrep.2018.03.013.
PubMed Link >

Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway

Pekmezci M, Stevers M, Phillips JJ, Van Ziffle J, Bastian BC, Tsankova NM, Kleinschmidt-DeMasters BK, Rosenblum MK, Tihan T, Perry A, Solomon DA.

Acta Neuropathol. 2018; 135 (3): 485-488. doi: 10.1007/s00401-018-1820-4. Epub 2018 Feb 10.
PubMed Link >

A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle

Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips JJ, Wiita AP, Yeh I, Jacobson MP, Bastian BC, Perry A, Solomon DA.

Nat Commun. 2018 Feb 23; 9 (1): 810. doi: 10.1038/s41467-018-02826-8.
PubMed Link >

Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and Progressive Glioblastoma

Byron SA, Tran NL, Halperin RF, Phillips JJ, Kuhn JG, de Groot JF, Colman H, Ligon KL, Wen PY, Cloughesy TF, Mellinghoff IK, Butowski NA, Taylor JW, Clarke JL, Chang SM, Berger MS, Molinaro AM, Maggiora GM, Peng S, Nasser S, Liang WS, Trent JM, Berens ME, Carpten JD, Craig DW, Prados MD.

Clin Cancer Res. 2018 Nov 5; 24 (2): 295-305. doi: 10.1158/1078-0432.CCR-17-0963. Epub 2017 Oct 26.
PubMed Link >

Diffuse midline gliomas with subclonal H3F3A K27M mutation and mosaic H3.3 K27M mutant protein expression

Lopez GY, Oberheim Bush NA, Phillips JJ, Bouffard JP, Moshel YA, Jaeckle K, Kleinschmidt-DeMasters BK, Rosenblum MK, Perry A, Solomon DA.

Acta Neuropathol. 2017; 134 (6): 961-963. doi: 10.1007/s00401-017-1780-0. Epub 2017 Oct 23.
PubMed Link >

Protein Analysis of Glioblastoma Primary and Posttreatment Pairs Suggests a Mesenchymal Shift at Recurrence

Wood MD, Reis GF, Reuss DE, Phillips JJ.

J Neuropathol Exp Neurol. 2016; 75 (10): 925-935. Epub 2016 Aug 18.
PubMed Link >

Characterization of Metabolic, Diffusion, and Perfusion Properties in GBM: Contrast-Enhancing versus Non-Enhancing Tumor

Autry A, Phillips JJ, Maleschlijski S, Roy R, Molinaro AM, Chang SM, Cha S, Lupo JM, Nelson SJ.

Transl Oncol. 2017; 10 (6): 895-903. doi: 10.1016/j.tranon.2017.08.009. Epub 2017 Sep 22.
PubMed Link >

Heparan Sulfate Glycosaminoglycans in Glioblastoma Promote Tumor Invasion

Tran VM, Wade A, McKinney A, Chen K, Lindberg OR, Engler JR, Persson AI, Phillips JJ.

Mol Cancer Res. 2017; 15 (11): 1623-1633. doi: 10.1158/1541-7786.MCR-17-0352. Epub 2017 Aug 4.
PubMed Link >

Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1

Mazor T, Chesnelong C, Pankov A, Jalbert LE, Hong C, Hayes J, Smirnov IV, Marshall R, Souza CF, Shen Y, Viswanath P, Noushmehr H, Ronen SM, Jones SJM, Marra MA, Cairncross JG, Perry A, Nelson SJ, Chang SM, Bollen AW, Molinaro AM, Bengtsson H, Olshen AB, Weiss S, Phillips JJ, Luchman HA, Costello JF.

Proc Natl Acad Sci U S A. 2017 Oct 3; 114 (40): 10743-10748. doi: 10.1073/pnas.1708914114. Epub 2017 Sep 15.
PubMed Link >