Phillips Lab at UCSF

Publications

The following includes a selection of recent publications from our lab. View the complete list here on PubMed.

 

Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy

Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA.

Neuro Oncol. 2017 May 1; 19 (5): 699-709. doi: 10.1093/neuonc/now254. Erratum in: Neuro Oncol. 2017 Apr 1;19(4):601.
PubMed Link >

Quantitative multi-modal MR imaging as a non-invasive prognostic tool for patients with recurrent low-grade glioma

Neill E, Luks T, Dayal M, Phillips JJ, Perry A, Jalbert LE, Cha S, Molinaro A, Chang SM, Nelson SJ.

J Neurooncol. 2017; 132 (1): 171-179. doi: 10.1007/s11060-016-2355-y. Epub 2017 Jan 25.
PubMed Link >

Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression

Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM.

Nat Cell Biol. 2016; 18 (12): 1336-1345. doi: 10.1038/ncb3429. Epub 2016 Nov 7.
PubMed Link >

Timing and significance of pathological features in C9orf72 expansion-associated frontotemporal dementia

Vatsavayai SC, Yoon SJ, Gardner RC, Gendron TF, Vargas JN, Trujillo A, Pribadi M, Phillips JJ, Gaus SE, Hixson JD, Garcia PA, Rabinovici GD, Coppola G, Geschwind DH, Petrucelli L, Miller BL, Seeley WW.

Brain. 2016; 139 (Pt 12): 3202-3216. Epub 2016 Oct 22.
PubMed Link >

Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma

Han SJ, Reis G, Kohanbash G, Shrivastav S, Magill ST, Molinaro AM, McDermott MW, Theodosopoulos PV, Aghi MK, Berger MS, Butowski NA, Barani I, Phillips JJ, Perry A, Okada H.

J Neurooncol. 2016; 130 (3): 543-552. Epub 2016 Sep 13.
PubMed Link >

Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process

Ohba S, Mukherjee J, Johannessen TC, Mancini A, Chow TT, Wood M, Jones L, Mazor T, Marshall RE, Viswanath P, Walsh KM, Perry A, Bell RJ, Phillips JJ, Costello JF, Ronen SM, Pieper RO.

Cancer Res. 2016 Nov 15; 76 (22): 6680-6689. doi: 10.1158/0008-5472.CAN-16-0696. Epub 2016 Oct 6.
PubMed Link >

Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation

Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Jin LW, Bastian BC, Bollen AW, Perry A, Nicolaides T, Solomon DA, Shieh JT.

Acta Neuropathol. 2016; 132 (5): 757-760. Epub 2016 Sep 13.
PubMed Link >

MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival

Radoul M, Chaumeil MM, Eriksson P, Wang AS, Phillips JJ, Ronen SM.

Mol Cancer Ther. 2016; 15 (5): 1113-22. doi: 10.1158/1535-7163.MCT-15-0769. Epub 2016 Feb 16.
PubMed Link >

Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells

Lerner RG, Grossauer S, Kadkhodaei B, Meyers I, Sidorov M, Koeck K, Hashizume R, Ozawa T, Phillips JJ, Berger MS, Nicolaides T, James CD, Petritsch CK.

Cancer Res. 2015 Dec 15; 75 (24): 5355-66. doi: 10.1158/0008-5472.CAN-14-3689. Epub 2015 Nov 16.
PubMed Link >

Pro-angiogenic cellular and genomic expression patterns within glioblastoma influences dynamic susceptibility weighted perfusion MRI

Barajas RF Jr, Phillips JJ, Vandenberg SR, McDermott MW, Berger MS, Dillon WP, Cha S.

Clin Radiol. 2015; 70 (10): 1087-95. doi: 10.1016/j.crad.2015.03.006. Epub 2015 Jul 29.
PubMed Link >

IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism

Izquierdo-Garcia JL, Viswanath P, Eriksson P, Cai L, Radoul M, Chaumeil MM, Blough M, Luchman HA, Weiss S, Cairncross JG, Phillips JJ, Pieper RO, Ronen SM.

Cancer Res. 2015 Aug 1; 75 (15): 2999-3009. doi: 10.1158/0008-5472.CAN-15-0840. Epub 2015 Jun 4.
PubMed Link >

Glycosylation alterations in lung and brain cancer

Lemjabbar-Alaoui H, McKinney A, Yang YW, Tran VM, Phillips JJ.

Adv Cancer Res. 2015 Feb 7; 126: 305-44. doi: 10.1016/bs.acr.2014.11.007. Epub 2015 Feb 7. Review.
PubMed Link >

SULF2, a heparan sulfate endosulfatase, is present in the blood of healthy individuals and increases in cirrhosis

Singer MS, Phillips JJ, Lemjabbar-Alaoui H, Wang YQ, Wu J, Goldman R, Rosen SD.

Clin Chim Acta. 2015 Feb 2; 440: 72-8. doi: 10.1016/j.cca.2014.10.038. Epub 2014 Oct 31.
PubMed Link >

Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma

Chaumeil MM, Larson PE, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM.

Cancer Res. 2014 Aug 15; 74 (16): 4247-57. doi: 10.1158/0008-5472.CAN-14-0680. Epub 2014 May 29.
PubMed Link >

Matrix regulators in neural stem cell functions

Wade A, McKinney A, Phillips JJ.

Biochim Biophys Acta. 2014; 1840 (8): 2520-5. doi: 10.1016/j.bbagen.2014.01.017. Epub 2014 Jan 18. Review.
PubMed Link >